Recherche

Page web : https://www.college-de-france.fr/​site/​en-cirb/​germain.htm.

1The sequence of biological events that permits an organism to maintain tissue viability in hypoxia remains poorly understood. Variations in oxygen concentration lead to respiratory, metabolic and vascular adaptations in tissues. How hypoxic endothelial cells (EC) integrate chemical signals with mechanical cues from their local tissue microenvironment in order to produce functional capillary networks that exhibit specialized form remains an open question. A key role of hypoxia in the regulation of many endothelial functions (Ferratge et al.) is nevertheless well established and growing evidence show that angiogenesis, defined as the events leading to blood vessels formation by sprouting or growth of preexisting vessels, can be triggered by hypoxia, both during development and in pathological conditions such as in muscle (Latroche et al.; Gitiaux et al.), in cardiovascular ischemia (Bouleti et al.; Garcia et al.) and tumors (Bousseau et al.). Our team is also interested in understanding how angiogenesis and vascular integrity are regulated in hypoxic conditions. We are also analyzing ECM composition, deposition, posttranslational modifications and rearrangement by ECs. We studied ow vascular ECM is organized and scaffolded to provide structural support for blood vessels and described how it regulates endothelial cell and pericyte functions and how it is required for proper vascular morphogenesis and maintenance of vascular homeostasis (Germain et al.; Marchand et al.).

Publications

2Bouleti C., Monnot C. et Germain S., « ANGPTL4, a multifaceted protein at the cross-talk between metabolism and cardiovascular disorders », International Journal of Cardiology, vol. 256, 2018, p. 2, DOI : 10.1016/j.ijcard.2017.10.123.

Latroche C., Weiss-Gayet M., Muller L., Gitiaux C., Leblanc P., Liot S., Ben-Larbi S., Abou-Khalil R., Verger N., Bardot P., Magnan M., Chrétien F., Mounier R., Germain S. et Chazaud B., « Coupling between myogenesis and angiogenesis during skeletal muscle regeneration is stimulated by restorative macrophages », Stem Cell Reports, vol. 9, n^o 6, 2017, p. 2018-2033, DOI : 10.1016/j.stemcr.2017.10.027.

Gitiaux C., Latroche C., Weiss-Gayet M., Rodero M.P., Duffy D., Bader Meunier B., Glorion C., Nusbaum P., Bodemer C., Mouchiroud G., Chelly J., Germain S., Desguerre I. et Chazaud B., « Myogenic progenitor cells exhibit IFN type I-driven pro-angiogenic properties and molecular signature during juvenile dermatomyositis », Arthritis & Rheumatology, vol. 70, n^o 1, 2018, p. 134-145, DOI : 10.1002/art.40328.