Régulation moléculaire de la synaptogenèse chez la souris / Mice, molecules and synapse formation
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Pages web : https://www.college-de-france.fr/molecular-identity-and-diversity-of-synapses-in-the-brain ; https://www.fekrijeselimilab.com.
1The mature brain is composed of morphologically and functionally distinct neuronal populations that form specific connections. This connectivity relies on the recognition of the target and of a precise subcellular domain for synapse formation. In humans, synapse formation is at its peak around birth, and this perinatal period is particularly sensitive to environmental factors that contribute to the etiology of neurodevelopmental and psychiatric disorders. This synaptogenic phase is followed by refinement of the networks through synapse stabilization or elimination. Furthermore, specific plasticity mechanisms enable the adaptation of the synapses to a changing environment through strengthening and weakening. Hence, each type of neuron integrates information received through several types of synapses that are characterized by a specific identity in terms of morphology, territory and function. The mammalian brain contains a huge diversity of synapses, the extent of which is only beginning to be deciphered. Our team’s overarching goal is to decipher the molecular basis of synapse identity, its modulation by environmental factors during early postnatal development and its relationship with the etiology of neurodevelopmental disorders.
Publications
2Veleanu M., Urrieta-Chavez B., Sigoillot S.M., Paul M., Usardi A., Iyer K., Delagrange M., Doyle J.P., Heintz N., Bécamel C. et Selimi F., « Transient molecular changes and lasting synaptic effects in the cerebellum of the neonatal phencyclidine mouse model of schizophrenia », PNAS, vol. 119, no 21, 2022, art. e2122544119, https://doi.org/10.1073/pnas.2122544119.
3González-Calvo I., Cizeron M., Bessereau J.L. et Selimi F., « Synapse formation and function across species: ancient roles for CCP, CUB and TSP-1 structural domains », Frontiers in Neuroscience, vol. 16, 2022, art. 866444, https://doi.org/10.3389/fnins.2022.866444.
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Référence papier
Fekrije Selimi, « Régulation moléculaire de la synaptogenèse chez la souris / Mice, molecules and synapse formation », L’annuaire du Collège de France, 122 | 2026, 740.
Référence électronique
Fekrije Selimi, « Régulation moléculaire de la synaptogenèse chez la souris / Mice, molecules and synapse formation », L’annuaire du Collège de France [En ligne], 122 | 2026, mis en ligne le 18 décembre 2025, consulté le 09 février 2026. URL : http://journals.openedition.org/annuaire-cdf/21543 ; DOI : https://doi.org/10.4000/15e27
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