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Cranial morphological analysis and foramina of the skull base in a cohort of 75 patients with Moyamoya disease. A comparative study with fossil populations of Homo sapiens scanned from different regions

Analyse de la morphologie crânienne et des foramens de la base du crâne sur une cohorte de 75 patients souffrant de la maladie de Moyamoya. Étude comparative avec des scans de populations fossiles d’Homo sapiens issus de régions différentes
Anne-Laure Bernat, Anna Maria Kubicka, Éric Bardinet, Marc-Antoine Labeyrie, Vittorio Civelli, Romain Valabregue, Jiaming Hui et Antoine Balzeau

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1This doctoral research lies at the crossroads of biological and medical anthropology, adopting an interdisciplinary approach that integrates paleoanthropology, paleoimaging, and neurology. The project focuses on Moyamoya disease, a rare cerebrovascular disorder characterized by progressive stenosis of the terminal carotid arteries, variably compensated by the development of intra- and extracranial collateral networks involving the external carotid system. The central objective is to identify specific cranial morphological traits that may be implicated in the clinical severity of the disease and to explore their potential functional and evolutionary significance.

2The study is based on a retrospective cohort of 75 patients diagnosed with Moyamoya disease, for whom existing medical imaging data will be systematically analyzed. Three-dimensional reconstructions and morphometric analyses will be performed to characterize endocranial imprints, with a particular focus on the venous and meningeal networks, the foramina of the skull base – especially the carotid and spinosum foramina – and overall cranial thickness. These findings will be compared with documented fossil Homo sapiens specimens from diverse geographical origins, analyzed through imaging, in order to establish qualitative and quantitative comparative frameworks.

3We hypothesize that Moyamoya disease may present distinct cranial radiological signatures that correlate with clinical severity. Their comparison with fossil data could help elucidate whether such traits reflect functional adaptations and provide insights into the evolutionary history of cerebral vascularization and brain morphology.

4Beyond its immediate medical implications, this research holds broader scientific and societal value. It offers a renewed interpretation of endocranial imprints, which are rarely correlated with contemporary clinical data, and refines paleoanthropological perspectives on brain vascularization and function through the lens of clinical imaging. More broadly, it illustrates how rare pathologies can illuminate aspects of human evolutionary biology and underscores the relevance of interdisciplinary collaboration between medical sciences and the humanities.

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Anne-Laure Bernat, Anna Maria Kubicka, Éric Bardinet, Marc-Antoine Labeyrie, Vittorio Civelli, Romain Valabregue, Jiaming Hui et Antoine Balzeau, « Cranial morphological analysis and foramina of the skull base in a cohort of 75 patients with Moyamoya disease. A comparative study with fossil populations of Homo sapiens scanned from different regions »Bulletins et mémoires de la Société d’Anthropologie de Paris [En ligne], 38(S) | 2026, mis en ligne le 16 décembre 2025, consulté le 07 mars 2026. URL : http://journals.openedition.org/bmsap/16703 ; DOI : https://doi.org/10.4000/15hhc

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Auteurs

Anne-Laure Bernat

Department of Neurosurgery, Hôpital Lariboisière, AP-HP, Université de Paris, Paris, France ; HNHP UMR 7194, CNRS, MNHN, UPVD, Musée de l’Homme, Paris, France ; annelaurebernat[at]hotmail.fr

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Anna Maria Kubicka

Department of Zoology, Institute of Zoology, Poznan University of Life Sciences, Poznan, Poland

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Éric Bardinet

CENIR, ICM, Sorbonne Université, UMPC Université Paris 6, Paris, France

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Marc-Antoine Labeyrie

Department of Interventional Neuroradiology, Hôpital Lariboisière, AP-HP, Université de Paris, Paris, France

Vittorio Civelli

Department of Interventional Neuroradiology, Hôpital Lariboisière, AP-HP, Université de Paris, Paris, France

Romain Valabregue

CENIR, ICM, Sorbonne Université, UMPC Université Paris 6, Paris, France

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Jiaming Hui

HNHP UMR 7194, CNRS, MNHN, UPVD, Musée de l’Homme, Paris, France

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Antoine Balzeau

HNHP UMR 7194, CNRS, MNHN, UPVD, Musée de l’Homme, Paris, France

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